Entry and Stability of Cross-National Marriages in the United States

As more and more people move across borders, marriage is becoming an increasingly global affair. Yet cross-national marriage (CNM) migration has not received the scholarly attention it deserves. The present study examines the characteristics and marital stability of unions between U.S. nationals and their foreign-born (FB) spouses residing in the United States. Two data sources were used in the analysis—the American Community Survey (ACS) and the Survey of Income and Program Participation (SIPP). Our results indicated that, after controlling for race/ethnicity, socioeconomic background and marital history, marriages between U.S. nationals and their FB spouses who entered the United States as adults were less stable than unions between two native-born (NB) spouses. Compared with non-Hispanic Whites, Asian and Hispanic U.S. nationals were more prone to marry FB spouses. We also found that husband NB–wife FB marriages seemed to fare better than wife NB–husband FB types

Research Progress on the Effect of 5-Methyltetrahydrofolic Acid on Hyperhomocysteinemia in Pregnancy

As the association of hyperhomocysteinemia in pregnancy with preterm birth, abortion, preeclampsia and other pregnancy compli-cations has attracted increasing attention, 5-methyltetrahydrofolic acid has attracted much attention as a potential treatment. In this paper, the biological mechanism of 5-methyltetrahydrofolic acid, its relationship with hyperhomocysteinemia in pregnancy and clinical studies were reviewed to review the research progress of 5-methyltetrahydrofolic acid in regulating hyperhomocysteine levels in pregnancy. The purpose of this paper is to explore the role and infuence of 5-methyltetrahydrofolic acid in the management of hyperhomocysteinemia during preg-nancy

How Do Consumers Use Nutrition Labels on Food Products in the United States?

This study examined how consumers use food labels in the United States. Based on the results from the cluster analysis, eight nutrition label questions from the Health and Diet Survey fell into 2 categories of label usage: for shopping or for dietary decisions. Survey respondents reported equal or more consideration of nutrition-label information for dietary choices than for shopping decisions in 2008 compared with prior survey years. Female consumers, frequent label users, well-educated, consumers aged 50 to 59, or consumers with any health issues were significantly more likely to use food labels for all kinds of purposes than their corresponding counterparts

Sex Ratio and Sexual Size Dimorphism in a Toad-headed Lizard, Phrynocephalus guinanensis

Phrynocephalus guinanensis has sexual dimorphism in abdominal coloration, but its ontogenetic development of sexual size dimorphism (SSD) is unknown. Using mark-recapture data during four days each year from August from 2014 to 2016, we investigated the development of sex ratios, SSD, sex-specific survivorship and growth rates in a population of P. guinanensis. Our results indicated that the sex ratio of males to females was 1:2.8. Males had a lower survival rate (6%) than females (14%) across the age range from hatchling to adult, which supported the discovered female-biased sex ratio potentially associated with the low survival rate of males between hatchlings and juveniles. Male-biased SSD in tail length and head width existed in adults rather than in hatchling or juvenile lizards. The growth rates in body dimensions were undistinguishable between the sexes during the age from hatchling to juvenile, but the growth rate in head length from juvenile to adult was significantly larger in males than females. Average growth rate of all morphological measurements from hatchling to juvenile were larger compared with corresponding measurements from juvenile to adult, but only being significant in tail length, head width, abdomen length in females and snout-vent length in males. We provided a case study to strengthen our understanding of the important life history traits on how a viviparous lizard population can survive and develop their morphology in cold climates

A Novel Differential Log-Companding Amplifier for Biosignal Sensing

We proposed a new method for designing the CMOS differential log-companding amplifier which achieves significant improvements in linearity, common-mode rejection ratio (CMRR), and output range. With the new nonlinear function used in the log-companding technology, this proposed amplifier has a very small total harmonic distortion (THD) and simultaneously a wide output current range. Furthermore, a differential structure with conventionally symmetrical configuration has been adopted in this novel method in order to obtain a high CMRR. Because all transistors in this amplifier operate in the weak inversion, the supply voltage and the total power consumption are significantly reduced. The novel log-companding amplifier was designed using a 0.18 μm CMOS technology. Improvements in THD, output current range, noise, and CMRR are verified using simulation data. The proposed amplifier operates from a 0.8 V supply voltage, shows a 6.3 μA maximum output current range, and has a 6 μW power consumption. The THD is less than 0.03%, the CMRR of this circuit is 74 dB, and the input referred current noise density is 166.1 fA/Hz. This new method is suitable for biomedical applications such as electrocardiogram (ECG) signal acquisition

ScribFormer: Transformer Makes CNN Work Better for Scribble-based Medical Image Segmentation

Most recent scribble-supervised segmentation methods commonly adopt a CNN framework with an encoder-decoder architecture. Despite its multiple benefits, this framework generally can only capture small-range feature dependency for the convolutional layer with the local receptive field, which makes it difficult to learn global shape information from the limited information provided by scribble annotations. To address this issue, this paper proposes a new CNN-Transformer hybrid solution for scribble-supervised medical image segmentation called ScribFormer. The proposed ScribFormer model has a triple-branch structure, i.e., the hybrid of a CNN branch, a Transformer branch, and an attention-guided class activation map (ACAM) branch. Specifically, the CNN branch collaborates with the Transformer branch to fuse the local features learned from CNN with the global representations obtained from Transformer, which can effectively overcome limitations of existing scribble-supervised segmentation methods. Furthermore, the ACAM branch assists in unifying the shallow convolution features and the deep convolution features to improve model’s performance further. Extensive experiments on two public datasets and one private dataset show that our ScribFormer has superior performance over the state-of-the-art scribble-supervised segmentation methods, and achieves even better results than the fully-supervised segmentation methods. The code is released at https://github.com/HUANGLIZI/ScribFormer

Evolutionary and regulatory pattern analysis of soybean Ca2+ ATPases for abiotic stress tolerance

P2-type Ca2+ ATPases are responsible for cellular Ca2+ transport, which plays an important role in plant development and tolerance to biotic and abiotic stresses. However, the role of P2-type Ca2+ ATPases in stress response and stomatal regulation is still elusive in soybean. In this study, a total of 12 P2-type Ca2+ ATPases genes (GmACAs and GmECAs) were identified from the genome of Glycine max. We analyzed the evolutionary relationship, conserved motif, functional domain, gene structure and location, and promoter elements of the family. Chlorophyll fluorescence imaging analysis showed that vegetable soybean leaves are damaged to different extents under salt, drought, cold, and shade stresses. Real-time quantitative PCR (RT-qPCR) analysis demonstrated that most of the GmACAs and GmECAs are up-regulated after drought, cold, and NaCl treatment, but are down-regulated after shading stress. Microscopic observation showed that different stresses caused significant stomatal closure. Spatial location and temporal expression analysis suggested that GmACA8, GmACA9, GmACA10, GmACA12, GmACA13, and GmACA11 might promote stomatal closure under drought, cold, and salt stress. GmECA1 might regulate stomatal closure in shading stress. GmACA1 and GmECA3 might have a negative function on cold stress. The results laid an important foundation for further study on the function of P2-type Ca2+ ATPase genes GmACAs and GmECAs for breeding abiotic stress-tolerant vegetable soybean

Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry

Leonurine, a major bioactive component from Herba Leonuri, shows therapeutic potential for cardiovascular disease and stroke prevention in some preclinical experiments. The aim of this study is to characterize metabolites of leonurine in rats using high performance liquid chromatography coupled with tandem mass spectrometry (HPLC/MS/MS). The chromatographic separation was performed on an Agilent ZORBAX SB-C18 column using a gradient elution with acetonitrile/ammonium acetate buffer (10 mM, pH 4.0) solvent system. An information dependent acquisition (IDA) method was developed for screening and identifying metabolites of leonurine under positive ion mode. Compared with control, the interesting compound in the extracted ion chromatogram (XIC) of the in vivo samples was chosen and further identified by analyzing their retention times, changes in observed mass (Δm/z), and spectral patterns of product ion utilizing advanced software tool. For the first time, a total of three metabolites were identified, including two phase II metabolites generated by glucuronidation (M1) and sulfation (M2) and one phase I metabolite formed by O-demethylation (M3). Finally, the lead metabolite M1 was isolated from urine and its structure was characterized as leonurine-10-O-β-D-glucuronide by NMR spectroscopy (1H, 13C, HMBC, and HSQC)

Evolutionary analysis of mitochondrially encoded proteins of toad-headed lizards, Phrynocephalus, along an altitudinal gradient.

BACKGROUND: Animals living at high altitude must adapt to environments with hypoxia and low temperatures, but relatively little is known about underlying genetic changes. Toad-headed lizards of the genus Phrynocephalus cover a broad altitudinal gradient of over 4000 m and are useful models for studies of such adaptive responses. In one of the first studies to have considered selection on mitochondrial protein-coding regions in an ectothermic group distributed over such a wide range of environments, we analysed nineteen complete mitochondrial genomes from all Chinese Phrynocephalus (including eight genomes sequenced for the first time). Initial analyses used site and branch-site model (program: PAML) approaches to examine nonsynonymous: synonymous substitution rates across the mtDNA tree. RESULTS: Ten positively selected sites were discovered, nine of which corresponded to subunits ND2, ND3, ND4, ND5, and ND6 within the respiratory chain enzyme mitochondrial Complex I (NADH Coenzyme Q oxidoreductase). Four of these sites showed evidence of general long-term selection across the group while the remainder showed evidence of episodic selection across different branches of the tree. Some of these branches corresponded to increases in altitude and/or latitude. Analyses of physicochemical changes in protein structures revealed that residue changes at sites that were under selection corresponded to major functional differences. Analyses of coevolution point to coevolution of selected sites within the ND4 subunit, with key sites associated with proton translocation across the mitochondrial membrane. CONCLUSIONS: Our results identify mitochondrial Complex I as a target for environment-mediated selection in this group of lizards, a complex that frequently appears to be under selection in other organisms. This makes these lizards good candidates for more detailed future studies of molecular evolution